2022, Vol. 26 ›› Issue (32): 5217-5222

Autophagy and inflammation-induced alveolar bone metabolism

Song Na1, Liu Guanjuan1, Luo Shanshan1, Huo Hua1, Cheng Yuting1, Hong Wei2, Liao Jian1   

Abstract: BACKGROUND: Autophagy can remove damaged proteins or excessive organelles, help cells adapt to adverse environmental changes, and maintain intracellular environment stability and self-renewal. However, abnormalities or dysfunctions in autophagy will lead to bone metabolic diseases.
OBJECTIVE: To review the effect of autophagy on inflammation-induced alveolar bone metabolism.
METHODS: The first author searched PubMed, Web of Science, Geenmedical, WanFang, and CNKI databases for relevant articles published from January 2011 to November 2021. The search terms were “autophagy, osteoblasts, osteoclasts, NLRP3, bone metabolism” in English and Chinese, respectively. Finally, 63 articles were included in result analysis after screening, analyzing and summarizing.
RESULTS AND CONCLUSION: Autophagy has a protective effect on the body. Moderate activation of autophagy is conducive to maintaining the internal environment homeostasis in bone tissue, and disorder or abnormality of autophagy pathways may disturb the dynamic balance during bone remodeling, resulting in the occurrence of alveolar bone metabolic diseases. NLRP3 inflammasomes and autophagy have a bidirectional regulatory effect and autophagy may play an important role in the occurrence and development of metabolic diseases in the alveolar bone by regulating NLRP3 inflammasomes.
Key words: autophagy, osteoblast, osteoclast, NLRP3, bone metabolism, review