2022, Vol. 26 ›› Issue (32): 5242-5247

Long non-coding RNA and osteoporosis

Kang Teng1, Lan Fengjun2, Qin Hao2, Liu Gang1, 2   

Abstract: BACKGROUND: In recent years, it has been found that the expression of long non-coding RNA molecules is closely related to the occurrence and development of osteoporosis and plays an important role in it. However, the underlying molecular mechanism has not yet been clarified.
OBJECTIVE: To review the role and mechanism of long non-coding RNA in the occurrence and development of osteoporosis, in an attempt to provide a new idea and approach for long non-coding RNA in the prevention and treatment of osteoporosis
METHODS: PubMed, CNKI, and WanFang databases were searched for relevant literature using the keywords of “long non-coding RNA, osteoporosis, mesenchymal stem cells, osteoblasts, osteoclasts, cellular pathways” in English and Chinese. Fifty-nine articles were enrolled for further analysis after excluding obsolete, repetitive and unreliable literature.
RESULTS AND CONCLUSION: Long non-coding RNAs can be involved in the prevention and treatment of osteoporosis by regulating and inhibiting the osteogenic differentiation of bone marrow and adipose mesenchymal stem cells. Long non-coding RNAs can promote osteoblasts and inhibit the proliferation of osteoclasts to influence the occurrence and development of osteoporosis. The regulation of long non-coding RNAs induces the activation or inhibition of osteoblast-related cellular pathways, thus altering the expression of target genes to participate in the procession of osteoporosis. Therefore, further studies on the role of long non-coding RNA in the pathogenesis of osteoporosis are helpful to provide a new idea and method for the early prevention and clinical treatment of osteoporosis.
Key words: long non-coding RNA, osteoporosis, mesenchymal stem cell, osteoblast, osteoclast, cellular pathway