2022, Vol. 26 ›› Issue (34): 5504-5511

Application of manganese in biomaterials: current situation and problems

Zhang Chang1, Yu Zhengwen1, 2   

Abstract: BACKGROUND: Metal elements play an important role in the human body. In recent years, the application of metal elements in biomaterials has attracted attention, and its functions and effects are being rapidly explored and broadened. Compared with the metal elements that have been studied more in recent years, such as magnesium and zinc, manganese is a rising star in the field of biomaterials research.
OBJECTIVE: To summarize and review application status and existing problems of manganese in biomaterials.
METHODS: The first author searched CNKI, Wanfang, ScienceDirect, and PubMed databases by computer to retrieve all relevant articles published from February 2010 to February 2021. The Chinese search terms were “manganese, biomaterials, biomedical metallic materials, ceramic biomaterial, nanomaterial, biopolymer material, bone tissue engineering, drug delivery, cancer therapy”, and the English search terms were “manganese, biomaterials, alloy, degradable metals, corrosion, biomedical metallic materials, ceramic biomaterial, nanomaterial, biopolymer material, bone tissue engineering, drug delivery, cancer therapy”. Finally, 72 included articles were summarized.
RESULTS AND CONCLUSION: (1) The current research found that the introduction of manganese into biomaterials can significantly improve the mechanical properties and corrosion resistance of biomaterials, and effectively improve the biocompatibility, bone formation and antibacterial properties of biomaterials, indicating that the incorporation of manganese ions as functional ions into biological materials has good research value. (2) The current research on manganese ions in biomaterials mainly focuses on in vivo and in vitro experiments. The existing studies have shown that combining manganese ions with collagen-hydroxyapatite scaffolds can promote osteogenesis of bone marrow mesenchyme stem cells in vitro and regeneration of new bone in mouse skull defects, and further enhance the osteoinductivity. (3) In view of the excellent properties of manganese, it can have broad application prospects in medical metal materials, bone tissue engineering materials, drug delivery, and tumor treatment. It is expected to provide a new direction for the basic and clinical applications of manganese-related biomaterials in the future.
Key words: manganese, biomaterial, biomedical metallic material, ceramic biomaterial, nanomaterial, biopolymer material, bone tissue engineering, drug delivery, cancer therapy, review