2022, Vol. 26 ›› Issue (34): 5543-5552

Effect of crown restoration and crown prosthesis on periodontal tissue and periodontal biomarkers

Zhang Jing, Zhang Zhao   

Abstract: BACKGROUND: As a common dental material for repairing tooth defects, crown prosthesis has an influence on the oral periodontium, especially the microecological environment in gingival crevicular fluid, which may be represented by the change of some biomarkers in gingival crevicular fluid.
OBJECTIVE: By analyzing causes and research progress on application of periodontal biomarkers affected by crown restoration, the effect was evaluated, and the influence of crown restoration on periodontal tissue was revealed microcosmically, in order to guide the selection of crown restoration in clinical practice.
METHODS: We searched relevant articles included in CNKI, Wanfang Data, Chinese Science and Technology Journal Database, and PubMed database with the keywords of “Crown restoration; Gingival crevicular fluid; Periodontal; Inflammation; Biomarker” in Chinese and English, and 63 articles were included for summary.
RESULTS AND CONCLUSION: (1) The periodontal tissue can be affected by different materials, crown edge tightness and preparation form, crown edge position, axial plane morphology and other aspects. (2) The biomarkers involved in periodontium affected by crown restoration include bacteria, inflammatory mediators, enzymes, and bone resorption biomarkers. (3) After crown restoration, the increased levels of Streptococcus mutans, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, interleukin 1, interleukin 6, tumor necrosis factor α, aspartate transferase, alkaline phosphatase, matrix metalloproteinase 8, and nuclear factor kappa B receptor activator ligand/osteoprotegerin in the gingival crevicular fluid can indicate the inflammatory state of periodontal tissue. The dynamic monitoring of these biomarkers is helpful to evaluate the adaptability of crown restoration to periodontal tissue, so as to provide clinical convenience for the reasonable application of crown restoration.  
Key words: crown restoration, gingival crevicular liquid, biomarkers, inflammation, bacteria, inflammatory mediator, enzyme, bone resorption