2022, Vol. 26 ›› Issue (35): 5716-5723

Effect and mechanism of non-coding RNA regulating autophagy in myocardial ischemia-reperfusion injury

Fan Jilin1, Zhu Tingting2, Tian Xiaoling2, Liu Sijia3, Su Jing3, Zhang Shiliang3   

Abstract: BACKGROUND: Increasing studies have shown that autophagy plays an important role in myocardial ischemia-reperfusion injury and moderate autophagy   help maintain the normal and metabolic function of the heart. Non-coding RNAs, including long non-coding RNAs, circular RNAs, and microRNAs, can maintain cardiomyocyte homeostasis and protect cardiomyocytes by regulating autophagy.
OBJECTIVE: To review the role and molecular mechanism of non-coding RNAs in regulating autophagy in myocardial ischemia-reperfusion injury, in order to lay a foundation for the treatment of myocardial ischemia-reperfusion injury and other related cardiovascular diseases.
METHODS: PubMed, Web of Science, WanFang and CNKI databases were searched for relevant literature published from January 2011 to January 2021 using the keywords of “noncoding RNAs, non-coding RNAs, long non-coding RNA, circRNA, microRNA, miRNA, autophagy, myocardial ischemia-reperfusion injury” in English and Chinese. The inclusion and exclusion criteria were formulated and 78 related documents were finally included by reading the titles, abstracts and full-text contents.
RESULTS AND CONCLUSION: Autophagy plays a dual role in the pathology of myocardial ischemia-reperfusion injury. Under physiological conditions, moderate autophagy can maintain the balance of cell metabolism and promote the survival of cardiomyocytes by degrading and recovering damaged organelles and proteins, but excessive autophagy will aggravate the damage of cardiomyocytes. Non-coding RNA regulating autophagy may become a new target for the development of diagnosis and therapeutic drugs. In addition, it is reasonable to think that the study on the mechanism of autophagy and non-coding RNAs can provide a new strategy for the prevention and treatment of myocardial ischemia-reperfusion injury.
Key words: non-coding RNA, lncRNA, circRNA, miRNA, myocardial ischemia-reperfusion injury, autophagy, review