2022, Vol. 26 ›› Issue (36): 5889-5896

Active components of flemingia in regulating the signaling pathways related to knee osteoarthritis

Lin Zhiyu, Han Jie, Ren Guowu, Chai Yuan, Wen Shuaibo, Wu Yukun, Xie Xiaozhong, Jin Wanqing   

Abstract: BACKGROUND: As a common disease of the elderly, the etiology and pathogenesis of knee osteoarthritis have not been clearly defined, and due to its high incidence and high disability rate, it seriously affects the quality of life of patients, requiring active prevention and treatment. Studies have confirmed that flemingia has a significant effect on the prevention and treatment of knee osteoarthritis; and studying its mechanism is of great significance.  
OBJECTIVE: By reviewing relevant articles at home and abroad, the research progress of flemingia in the prevention and treatment of knee osteoarthritis was reviewed based on the mechanism-related signaling pathways, providing ideas and reference for the effective prevention and treatment of knee osteoarthritis.
METHODS: Relevant articles published from 2010 to 2020 were retrieved on CNKI, Wanfang, VIP, PubMed, MEDLINE, Cochran and Nature databases. A total of 60 articles were included through inclusion and exclusion criteria to exclude duplicated and old articles.  
RESULTS AND CONCLUSION: (1) The main active components of flemingia include genistein, stigmasterol, emodin, chrysophanol, and ononin. (2) The active components of flemingia play an anti-inflammatory role in promoting osteoblast proliferation and differentiation and regulating chondrocyte apoptosis to delay the accelerated progression of knee osteoarthritis. The main regulatory pathways contain Notch, JAK2/STAT3, nuclear factor-κB, MAPK and other related signaling pathways.
Key words: flemingia, knee osteoarthritis, inflammation, osteogenesis, apoptosis, bone tissue engineering, signaling pathway, review