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2022, Vol. 26 ›› Issue (5): 657-662

Feasibility of ultrasound-guided intra-articular injection in rabbit hip joint

Wang Shaoling, Wang Yanxue, Zheng Yaochao, Yu Shaojun, Ma Chao, Wu Shaoling   

  1. Department of Rehabilitative Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China

  • Received:2020-11-06 Revised:2020-11-11 Accepted:2020-12-14 Online:2022-02-18 Published:2021-10-28

  • Contact: Wu Shaoling, MD, Doctoral supervisor, Chief physician, Department of Rehabilitative Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China

  • About author:Wang Shaoling, Master candidate, Department of Rehabilitative Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China

  • Supported by:

    the National Natural Science Foundation of China, No. 81671088 (to WSL) and 81972152 (to MC); Yat-sen Clinical Research and Cultivation Routine Project of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. SYS-C-202002 (to WSL)



Abstract: BACKGROUND: In the past, fluoroscopy guidance was the first choice for guiding hip injections. Recently, ultrasound has become increasingly popular in intra-articular injections due to its portability, non-radiation, low cost, and high accuracy.
OBJECTIVE: To compare the accuracy of ultrasound-guided intra-articular treatment and fluoroscopy-guided injection in rabbit hip joint and to determine whether ultrasound guidance is a suitable method for intra-articular injection.
METHODS: High-resolution ultrasound and fluoroscopy were used for visualized injections. New Zealand rabbits (n=16, a total of 64 hip joints injected in two rounds) were randomly divided into two groups before each round. Injections were guided by the high-resolution ultrasound or by the fluoroscopy using an X-ray machine with wireless flat-panel detector. The distribution of iohexol was detected by computed tomography after injections. To determine whether ultrasound guidance can significantly improve the accuracy of rabbit hip injections, we compared the accuracy, number of puncture attempts, and procedure time between two groups. The study protocol was approved by the Experimental Animal Ethics Committee of Sun Yat-sen University.

RESULTS AND CONCLUSION: A total of 32 hip joints were injected in each group, 29 of which were successfully injected in the ultrasound guidance group and 21 of which were successfully injected in the fluoroscopy guidance group. The accuracy rate of interventions in the ultrasound guidance group (90.6%) was significantly higher than that in the fluoroscopy guidance group (65.6%; P < 0.05). The number of puncture attempts in the ultrasound guidance group was significantly lower than that in the fluoroscopy guidance group (P < 0.05). There was no significant difference in the procedure time between two groups. Compared with fluoroscopy guidance, ultrasound-guided intra-articular treatment has a higher accuracy and no radiation, and needs fewer puncture attempts, which a suitable and feasible method for intra-articular injection in rabbit hip joint.

Key words:ultrasound, rabbit, hip joint, intra-articular injection, accuracy


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Chinese Association of Rehabilitation Medicine

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