|
|
2022, Vol. 26 ›› Issue (5): 768-773Hyaluronic acid around articular chondrocytes: production, transformation and function characteristicsXu Lei1, Han Xiaoqiang2, Zhang Jintao1, Sun Haibiao2
Abstract: BACKGROUND: Up to date, there is still no review on the metabolism and function of hyaluronic acid around articular chondrocytes. OBJECTIVE: To summarize the latest definition and experimental results of hyaluronic acid, thereby providing theoretical basis for the clinical application of hyaluronic acid. METHODS: The relevant literatures in CNKI, WanFang, and PubMed databases were searched by computer from the establishment of the database to November 2020. The keywords were “hyaluronic acid, cartilage, sodium hyaluronate, osteoarthritis, cartilage, chondrocytes” in Chinese and English, respectively. Finally, 75 eligible articles were included for further analysis. RESULTS AND CONCLUSION: Hyaluronic acid plays a variety of roles in the joint, especially in chondrocytes and its surrounding matrix. Hyaluronic acid provides a basic scaffold for proteoglycan aggregates, which can bear part of the cartilage load-bearing function. The pathway formed by hyaluronic acid and CD44 can transmit the information between cells and the surrounding matrix. Continuous turnover and renewal of hyaluronic acid and aggrecan can increase the ability of cartilage to resist external damages. Exogenous hyaluronic acid can protect cartilage, treat osteoarthritis, relieve pain, and even treat bone metastases. Key words:hyaluronic acid, cartilage, osteoarthritis, chondrocyte, review, sodium hyaluronate |