2022, Vol. 26 ›› Issue (5): 780-785

Molecular mechanism by which icariin regulates osteogenic signaling pathways in the treatment of steroid-induced avascular necrosis of the femoral head

Li Jiajun1, Xia Tian1, Liu Jiamin1, Chen Feng1, Chen Haote2, Zhuo Yinghong1, Wu Weifeng1

1Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China; 2China Academy of Chinese Medical Sciences, Beijing 100000, China

Received:2020-11-11 Revised:2020-11-14 Accepted:2020-12-18 Online:2022-02-18 Published:2021-12-02
Contact: Xia Tian, MD candidate, Associate professor, Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
About author:Li Jiajun, Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi Zhuang Autonomous Region, China
Supported by:
the Natural Science Foundation of Guangxi Zhuang Autonomous Region for the Youth, No. 2020GXNSFBA159053; Young Teachers' Basic Ability Improvement Project in Guangxi Universities, No. 2019KY0352; 2019 School-level Scientific Research Project of Guangxi University of Traditional Chinese Medicine, No. 2019QN027; First-class Subject Project of Guangxi University of Traditional Chinese Medicine, No. 2019XK029; 2016 National Famous Traditional Chinese Medicine Heritage Studio Construction Project, No. {2016}11; National College Student Innovation and Entrepreneurship Training Program, No. 202010600025 (to LJJ)

Abstract: BACKGROUND: Studies have confirmed that icariin can promote osteogenesis and prevent and treat steroid-induced avascular necrosis of the femoral head (SANFH). Understanding the drug-target-pathway regulation mechanism will be crucial for the effective treatment of SANFH.
OBJECTIVE: To review the research progress of icariin in the prevention and treatment of SANFH based on the mechanism by which icariin regulates osteogenesis through Wnt, PI3K/AKT, mTOR and estrogen signaling pathways, in order to provide ideas and reference for the effective prevention and treatment of SANFH.
METHODS: Relevant literatures published from 2014 to 2020 were retrieved from PubMed, Web of Science, CNKI, VIP and WanFang databases, using the keywords of “icariin, glucocorticoid, ONFH, osteonecrosis of the femoral head, signaling pathways, pathogenesis, Wnt, Wnt/β-catenin, PI3K/AKT, mTOR, ERs.” The old and repeated literatures were excluded, and a total of 56 literatures were finally included for analysis and discussion.

RESULTS AND CONCLUSION: Icariin can promote bone metabolism and improve blood circulation, and its mechanism of action in the treatment of SANFH has become the focus of research. Icariin can regulate Wnt, PI3K/AKT, mTOR, estrogen receptor and other related signaling pathways to play an osteogenic role in the treatment of SANFH. Icariin has a regulatory effect on the signaling pathways related to SANFH. However, relevant experimental studies have not yet been able to specify its mechanism of action, and there are also few relevant clinical studies. Therefore, explorations on icariin’s mechanism of action and its clinical application will be the focus and direction of research.

Key words:icariin, glucocorticoid, osteonecrosis of the femoral head, signaling pathway, pathogenesis, review

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