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2022, Vol. 26 ›› Issue (5): 792-797Sarcopenia: age-related muscle mass loss and functional declinesZheng Zhenquan, Rong Jiesheng
Abstract: BACKGROUND: Sarcopenia is defined as a syndrome of progressive reduction in age-related skeletal muscle mass, accompanied by declines in muscle strength and/or function, triggering a series of undesirable consequences such as accidental fractures. OBJECTIVE: To review the progress in the definition, measurement methods, correlation with fractures, prevention and treatment of sarcopenia. METHODS: PubMed and CNKI were searched for literatures related to sarcopenia using the keywords of “sarcopenia/muscular atrophy/muscle/fracture/treatment/prevention.” Keywords were searched alone and in combination, followed by full-text reading. RESULTS AND CONCLUSION: EWGSOP, IWGS, AWGS and other working groups have developed a standardized definition and diagnosis of sarcopenia. However, the criteria for defining sarcopenia vary slightly in literatures included in PubMed. Risk of fractures is increased in older adults with sarcopenia, and sarcopenia will have a worse effect in patients with osteoporosis. Animal experiments have verified that sarcopenia and osteoporotic fractures coexist in animal models, and sarcopenia can lead to delayed fracture healing. Exercise and nutrition intervention are currently used prevention and treatment programs. Osteocalcin, omega-3 polyunsaturated fatty acids, soluble activin IIB receptor and stem cell transplantation have great potential in the treatment of sarcopenia. Key words:sarcopenia, diagnosis, fracture, prevention, treatment, review |