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2022, Vol. 26 ›› Issue (5): 798-803Exercise regulates adult hippocampal neurogenesis in Alzheimer’s disease: mechanism and roleTang Jiping, Zhang Yeting
Abstract: BACKGROUND: Studies have found that exercise can regulate adult hippocampal neurogenesis and improve cognitive function in patients with Alzheimer’s disease. However, the mechanism by which exercise affects adult hippocampal neurogenesis and improves cognitive function in patients with Alzheimer’s disease is not clear. OBJECTIVE: To analyze and summarize how exercise affects adult hippocampal neurogenesis and the mechanism of adult hippocampal neurogenesis in improving Alzheimer’s disease. METHOD: Literature search (from inception to December 2020) was performed in CNKI and Web of Science databases (including WOS, DIIDW, INSPEC, KJD, MEDLINE, RSCI, SCIELO) using “exercise, neurogenesis, AHN, Alzheimer’s disease, aging, cognition” as keywords, to investigate the effects of exercise on Alzheimer’s disease and adult hippocampal neurogenesis. All enrolled literatures were analyzed and reviewed according to certain logic. RESULTS AND CONCLUSION: Exercise can regulate the overall dynamic balance of neuronal niche by increasing the proliferation of astrocytes and enhancing the secretion of glucose transporter 1, vascular endothelial growth factor, and brain-derived neurotrophic factor, so as to promote adult hippocampal neurogenesis in patients with Alzheimer’s disease patients. However, this process is affected by mediators, growth factors or neurotrophic factors, such as glutamate, γ-aminobutyric acid, 5-hydroxytryptamine, vascular endothelial growth factor, N-methyl-d-aspartic acid, and brain-derived neurotrophic factor. Key words:exercise, Alzheimer’s disease, adult hippocampal neurogenesis, cognition, neurotrophic factor |