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2022, Vol. 26 ›› Issue (6): 980-984Improvement of the treatment effect of osteoporotic fractures: research status and strategy analysisPeng Kun
Abstract: BACKGROUND: With the increasing aging of China’s population, the number of people with osteoporotic fracture is also gradually increasing. How to improve the treatment effect and improve people’s healthy living standards is attracting the attention of clinicians, engineers and researchers. OBJECTIVE: To review the research progress of improving the treatment effect of osteoporotic fracture, and propose a improvement plan of treatment effect. METHODS: The relevant articles were searched from Wanfang Medical Database, CNKI Database, PubMed Database, and Elsevier Database by computer. The search terms were “osteoporosis, fractures, surgical treatment, implants, anti-osteoporosis treatment, growth factors” in Chinese and English. The time was limited from 2010 to 2020. Finally, 48 articles were included for review. RESULTS AND CONCLUSION: (1) At present, the therapeutic effect can be improved by optimizing surgical treatment and anti-osteoporosis treatment. The surgery of bone compression can improve fusion degree between the short-term implant and fracture site bone tissue. The use of locking plate fixation technology can improve the growth and recovery of bone tissue at the fracture site. During the operation, autogenous bone, allogeneic bone, artificial bone materials, and ceramic materials were used as implants, which could fill the bone defect, but there were still some problems , such as limited donor, secondary operation, immune rejection, and insufficient biological activity. (2) Biodegradable polymeric materials, with good biosecurity, biocompatibility, plasticity, and remodelability, are hotspot in the research of osteoporotic fracture repair materials. (3) The introduction of Epimedium, bisphosphonates, and other drugs achieved better therapeutic effect than surgery alone. (4) Mechano growth factor-Ct24E as a typical force growth factor is conducive to improving the therapeutic effect, which promotes the adhesion, proliferation, differentiation and mineralization of osteoblasts. (5) Individually designed orthopedic implants need to have a three-dimensional structure that conforms to the formation of bone tissue. Three-dimensional printing technology can provide a physical structure that matches the patient’s fracture site. (6) In addition, after comprehensively analyzing the therapeutic effects of four aspects, including surgical procedures, implants, drugs, and growth factors, the author thinks that using force growth factor, anti-osteoporosis drug, biodegradable polymer, composite implants, and the application of three-dimensional printing technology together, and cooperating with the surgical treatment of advanced technology, can promote the growth of bone tissue, improve bone quality, enhance fusion, and obtain proper three-dimensional structure, and achieve comprehensive improvement of the treatment effect of osteoporotic fractures. Key words:osteoporosis, fracture, bone compression, locking plate fixation, implant, anti-osteoporosis therapy, growth factor |