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2022, Vol. 26 ›› Issue (7): 1102-1106Application of engineered exosomes in bone repair and regenerationWu Weiyue, Guo Xiaodong, Bao Chongyun
Abstract: BACKGROUND: Bone defect caused by disease or accident is very common in clinic. The current main treatment method for bone defect repair is autologous bone grafting. Autologous bone grafting may cause complications, such as secondary infections and scars. The other treatments, such as allogeneic bone transplantation, may have risks of immune rejection and disease transmission. Furthermore, safety considerations and the performance of biomaterials and cell-based treatment require further clarification. In recent years, engineered exosomes have shown good application potential in bone repair and bone regeneration, and have become a current research hotspot. OBJECTIVE: To review the research progress of engineering exosomes in promoting bone defect repair and bone regeneration. METHODS: The PubMed, CNKI and Wanfang databases were searched for relevant articles with the key words of “exosome; engineered exosomes; bone repair; bone regeneration” in English and Chinese, respectively. The search time was from January 1980 to September 2020. Articles that were not related to the purpose of the research and repetitive articles were excluded, and 56 articles that met the criteria were finally included for review. RESULTS AND CONCLUSION: The engineered exosomes can not only promote bone differentiation of osteoblast-related cells and new blood vessel formation, but also target tissues and cells. A large number of experiments have proven that the engineered exosomes for repairing bone defect and promoting bone regeneration is a feasible strategy. Key words:exosome, engineered exosomes, bone repair, bone regeneration, bone defect, review |