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2022, Vol. 26 ›› Issue (7): 1107-1112Exosomes that deliver specific miRNAs can regulate osteogenesis and promote angiogenesisZhou Hongqin, Wu Dandan, Yang Kun, Liu Qi
Abstract: BACKGROUND: Exosomes are nanoscale paracrine vesicles containing a variety of bioactive factors, such as miRNAs. Exosome miRNAs play an important role in intercellular communication. In recent years, more and more studies have focused on whether miRNAs in exosomes promote bone regeneration. OBJECTIVE: To review research status of exosomal miRNAs promoting bone regeneration in the recent years so as to provide a theoretical basis for further research and application in the field of bone regeneration. METHODS: Using “bone regeneration, bone repair, exosomes, miRNA” in Chinese and English as search terms, biomedical literature database, CNKI, and PubMed were retrieved for articles on exosomal miRNA and bone regeneration published from 2010 to 2021. RESULTS AND CONCLUSION: Exosomes derived from different cells can effectively regulate osteogenesis and promote angiogenesis through the delivery of specific miRNAs, which has a broad prospect in bone tissue engineering. Key words:cell, exosome, miRNA, bone regeneration, bone repair, review |