2022, Vol. 26 ›› Issue (7): 1113-1118

Mechanism and application of stem cell-derived exosomes in promoting diabetic wound healing

Zhang Jinglin, Leng Min, Zhu Boheng, Wang Hong

Department of Burns, the Second Affiliated Hospital, Kunming Medical University, Burn Institute of Yunnan Province, Kunming 650101, Yunnan Province, China

Received:2020-09-27 Revised:2020-09-28 Accepted:2020-11-09 Online:2022-03-08 Published:2021-10-29
Contact: Wang Hong, Master, Chief physician, Department of Burns, the Second Affiliated Hospital, Kunming Medical University, Burn Institute of Yunnan Province, Kunming 650101, Yunnan Province, China
About author:Zhang Jinglin, Master candidate, Physician, Department of Burns, the Second Affiliated Hospital, Kunming Medical University, Burn Institute of Yunnan Province, Kunming 650101, Yunnan Province, China
Supported by:
National Natural Science Foundation of China Regional Science Foundation Supported Project, No. 81660321 (to WH); Yunnan Provincial Department of Science and Technology - Kunming Medical University Applied Basic Research Joint Special Funding Project, No. 2017FE468(-177) (to WH)

Abstract: BACKGROUND: The exosomes are one of important active components of adult stem cells paracrine, providing the basis for stem cell “non-cellular” treatment. Exosomes from stem cells can play different roles in the wound through different mechanisms to promote the healing of diabetic wounds.
OBJECTIVE: To summarize the main mechanism and application of stem cell derived exosomes in the treatment of diabetic wounds.
METHODS: Computers were used to retrieve English databases such as PubMed database, Web of Science database, FMRS foreign language medical information resource retrieval platform, and Chinese databases such as CNKI and Wanfang Data Knowledge Service Platform. The retrieval scope was from the inception of the database to September 2020. The English and Chinese search terms were “stem cells, exosomes, wound healing, cell proliferation, neovascularization, inflammation, extracellular matrix, therapeutic use”. According to the inclusion and exclusion criteria, 66 articles were included and the results were analyzed.

RESULTS AND CONCLUSION: (1) It is summarized that stem cell-derived exosomes can promote diabetic wound healing by regulating inflammation, promoting neovascularization, re-epithelialization and remodeling of extracellular matrix. (2) The application of stem cell-derived exosomes in diabetic wounds was listed. (3) The exosomes from stem cells can avoid the immune response of stem cells in the treatment of diabetic wounds, and the genetic material of stem cells carried by them is more widely regulated and more effective than that from ordinary cells in the treatment of diabetic wounds. (4) At present, the application of stem cell derived exosomes in diabetes wounds still has some problems, such as low purity, high cost of separation, low production efficiency, and the way to reach the target area, loss rate and diffusion efficiency.

Key words:stem cell, exosomes, diabetic wound, cell proliferation, neovascularization, wound healing, tissue engineering, review

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