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2022, Vol. 26 ›› Issue (7): 1125-1129Theoretical mechanism of traditional Chinese medicine theory on stem cell induced differentiationHui Xiaoshan1, Bai Jing1, 2, Zhou Siyuan1, Wang Jie1, Zhang Jinsheng3, He Qingyong1, Meng Peipei1
Abstract: BACKGROUND: In recent years, under the guidance of the theory of traditional Chinese medicine, scholars have made certain progress in using traditional Chinese medicine to intervene stem cell induction and differentiation into directional cells and/or tissues, which has gradually become a highlight and hotspot in the field of tissue engineering research. However, there are few articles on traditional Chinese medicine theory and stem cell induced differentiation. OBJECTIVE: To discuss the induction and differentiation of stem cells from traditional Chinese medicine theory and summarize its research and progress. METHODS: “Traditional Chinese medicine, theory, induced differentiation, mesenchymal stem cells” were respectively used as search words to retrieve Chinese Journal Full-Text Database, VIP, CBMdisc, Wanfang database, PubMed, and Web of Science from January 1978 to December 2019. With the comprehensive retrieval method of keywords combined with subject words, through the selection of text title and abstract, the author excluded the articles that were not correlated with the research purpose and lacked original and repetitive research, and summarized the 57 articles that finally met the standard. RESULTS AND CONCLUSION: The combination of traditional Chinese medicine theory and stem cell differentiation has been applied in the research of induced differentiation of many cells and tissues. In particular, some research achievements have been made in the differentiation and differentiation of stem cells by traditional Chinese medicine therapies and formulas, such as activating blood circulation and removing blood stasis, invigorating qi, nourishing kidney and filling essence. To explore the induction and differentiation of stem cells from traditional Chinese medicine theory can not only open up new directions for further in-depth study of stem cells, but also provide research ideas and guidance for the treatment of related diseases by traditional Chinese medicine, which may become a sign of modernization of traditional Chinese medicine and has great practical significance. Key words:stem cells, induction, differentiation, traditional Chinese medicine, theory, promoting blood circulation to remove blood stasis, review |