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2022, Vol. 26 ›› Issue (7): 1130-1136Potential of muscle-derived stem cells in peripheral nerve regenerationAn Weizheng, He Xiao, Ren Shuai, Liu Jianyu
Abstract: BACKGROUND: Muscle-derived stem cells have strong self-renewal and multi-directional differentiation potential, which has a wide application prospect in the field of nerve injury repair. OBJECTIVE: To review the treatment status of peripheral nerve injury and research progress of muscle-derived stem cells in the treatment of peripheral nerve injury. METHODS: “Muscle-derived stem cell, peripheral nerve injury, tissue engineering, Schwann cell, transplant, regeneration, nerve conduit” were the search words. The articles in PubMed, CNKI and Wanfang databases were cross-searched. After excluding repetitive research and irrelevant articles, 100 articles were finally included for review. RESULTS AND CONCLUSION: Muscle-derived stem cells show good regenerative potential in repairing nerve injury by differentiating into various kinds of support cells needed for nerve regeneration and powerful secretory function. Key words:muscle-derived stem cells, peripheral nerve injury, Schwann cells, transplantation, nerve conduit, regeneration, neurotrophic factor, tissue engineering, differentiation, review |