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2022, Vol. 26 ›› Issue (8): 1202-1209Bibliometric and visualized analysis of ferroptosis mechanism researchLi Zhiyi1, He Pengcheng1, Bian Tianyue1, Xiao Yuxia1, Gao Lu2, Liu Huasheng1
Abstract: BACKGROUND: Ferroptosis is a novel form of regulated cell death, characterized by iron-dependent polyunsaturated fatty acids peroxidation and subsequent plasma membrane rupture. Ferroptosis is involved in numerous diseases. OBJECTIVE: To understand the trends and hot spots of ferroptosis by analyzing Chinese and English literatures related to ferroptosis based on bibliometric and visualized analysis. METHODS: We searched literatures related to ferroptosis in the Web of Science Core Collection and CNKI from 2012 to 2021, and analyzed the quantity, country, institution, author, journal, citations and keywords of literatures by CiteSpace software to generate a mapping knowledge domain. RESULTS AND CONCLUSION: The number of relevant literatures increased rapidly in recent years. Chinese researchers published the most number of literatures. Reference and keywords analysis showed that ferroptosis plays an important role in cancer, neurodegenerative diseases and ischemia reperfusion injury. Iron, lipid and glutathione metabolisms are the basic biological processes of ferroptosis. GPX4 and ACSl4 are the key enzymes in ferroptosis. NRF2, p53 and nuclear factor-κB are the most extensively described regulators of ferroptosis. Sorafenib promotes ferroptosis in tumor cells, while Erastin and vitamin E protect neurons from ferroptosis. They are the most popular drugs for ferroptosis. We should further research the mechanism of ferroptosis to provide more support for its translational applications in clinic. Nanoparticles combined with drugs or physical methods targeting ferroptosis bring a new and worthy therapeutic strategy. Key words:ferroptosis, bibliometric analysis, mapping knowledge domains, CiteSpace, cancer, neurodegenerative disease, ischemia-reperfusion injury, nanoparticle |