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2022, Vol. 26 ›› Issue (8): 1260-1265Role and mechanism of interleukin-3 in bone metabolismWang Jing1, Xiong Shan1, Cao Jin1, Feng Linwei2, Wang Xin1
Abstract: BACKGROUND: Bone defect and bone healing have always been two major clinical problems. In recent years, targeted cytokines such as Interleukin-3 have been used to treat certain bone diseases, such as rheumatoid arthritis and multiple myeloma. OBJECTIVE: To summarize the relationship between interleukin-3 and bone metabolism, and to understand the mechanism of interleukin-3 in osteogenesis, so as to provide theoretical reference for new osteogenesis programs. METHODS: PubMed and CNKI were retrieved by the first author for relevant articles published January 1990 to March 2021 and from January 1979 to March 2021, respectively. The search terms used were “interleukin-3, bone metabolism, osteoblast, osteoclast, bone formation, mesenchymal stem cells, vascularization” in English and Chinese, respectively. A total of 896 articles detailing the mechanism of interleukin-3 and osteogenesis related metabolism were initially searched, and finally 56 eligible articles were included for further review and analysis. RESULTS AND CONCLUSION: Different from other cytokines, interleukin-3 has multi-lineage targeting potential and plays an important role in hematopoietic system. Studies have shown that interleukin-3 can directly interact with mesenchymal stem cells and promote their osteogenic differentiation. In addition, interleukin-3 has been shown to positively regulate the osteogenic differentiation of mesenchymal stem cells by stimulating the synthesis of bone morphogenetic protein-2. Although interleukin-3 has an effect on bone marrow stromal osteoblasts through inhibition of bone morphogenetic protein-2, no effects of interleukin-3 on the Runx2 and β-catenin pathways have been found. Bone absorption by osteoclasts can lead to bone loss. Early studies found that interleukin-3 could promote osteoclasts, while recent studies have shown that interleukin-3 could significantly inhibit c-Fms at mRNA and protein levels, and down-regulate the expressions of PU.1 and c-Fos, thus producing an inhibitory effect on osteoclasts. Therefore, the specific mechanism of interleukin-3 in osteoblasts and osteoclasts is thoroughly reviewed in this paper, with a view to providing references for future studies. Key words:interleukin-3, osteogenesis, bone formation, osteoblasts, osteoclasts, mesenchymal stem cells, vascularization, review |