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2022, Vol. 26 ›› Issue (8): 1286-1292Application of platelet-rich plasma in neuropathic painKan Houming1, Fan Lijun1, Chen Xuetai1, Shen Wen2
Abstract: BACKGROUND: There is no specific treatment method for neuropathic pain. Patients suffer from chronic pain for a long time, which seriously affects the quality of life of patients. Platelet-rich plasma releases a variety of biologically active factors, has nerve repair and pain relief effects, and has great potential in neuropathic pain applications. OBJECTIVE: To discuss the principles of neuropathic pain and the theoretical basis of platelet-rich plasma in the treatment of neuropathic pain, expound the application of platelet-rich plasma in different types of neuropathic pain, in order to provide new ideas and methods for clinical treatment of neuropathic pain. METHODS: Using “platelet rich plasma, neuropathic pain, nerve injury, neuralgia” as search terms, VIP, WanFang, CNKI, Web of Science and PubMed databases were retrieved for relevant articles published from 1954 to February 2021. Finally, 107 articles eligible for the inclusion and exclusion criteria were included for result analysis. RESULTS AND CONCLUSION: Platelet-rich plasma has the potential to promote healing and anti-inflammation. It can repair damaged nerve tissues and effectively relieve pain. Platelet-rich plasma is an important treatment for neuropathic pain and has a bright future. The preparation method of platelet-rich plasma is still controversial, and there is a call for the establishment of standardized preparation methods and unified ingredient evaluation standards. Increasing studies on platelet-rich plasma has been made in the fields of spinal cord injury, peripheral nerve injury, and nerve compression. Further exploration is still needed on the application of platelet-rich plasma in the mechanism and clinical efficacy of other types of neuropathic pain. Key words:platelet rich plasma, neuropathic pain, nerve injury, neuralgia, spinal cord injury |