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2022, Vol. 26 ›› Issue (9): 1445-1451Role and therapeutic implications of pyroptosis in intervertebral disc degenerationZhang Haobo1, 2, Zhao Yunan1, 2, Yang Xuejun2
Abstract: BACKGROUND: Pyroptosis is a newly discovered type of pro-inflammatory programmed cell necrosis. It is found that cell pyroptosis plays an important role in the occurrence and development of intervertebral disc degeneration. Key words:pyroptosis, intervertebral disc degeneration, nucleus pulposus, extracellular matrix, activation, signal, interleukin-1β |