2023, Vol. 27 ›› Issue (10): 1626-1633

Regulation of Sema3A on oral mesenchymal stem cell function

Xing Guoyi1, 2, Sun Legang1, 2, Ma Xiangrui1, Wang Wenlong1   

Abstract: BACKGROUND: Studies have found that Sema3A can not only participate in tumor growth, angiogenesis, bone remodeling, immune regulation, and other biological and pathological processes, but also effectively promote the proliferation and differentiation of oral tissue-derived mesenchymal stem cells. Therefore, Sema3A may provide new ideas and potential new targets for the treatment of soft and hard tissue damage caused by oral diseases.  
OBJECTIVE: To summarize the various biological functions of Sema3A, focusing on the role of Sema3A in regulating the proliferation, differentiation, and inflammatory environment of oral tissue-derived mesenchymal stem cells and the research progress of related signaling pathways so as to provide a feasible solution for Sema3A to treat oral diseases and repair oral soft and hard tissue defects.
METHODS: Articles related to Sema3A and oral mesenchymal stem cells included in CNKI and PubMed databases from January 1993 to March 2022 were searched. A total of 70 articles were included for review.  
RESULTS AND CONCLUSION: (1) Sema3A has a great potential in the field of tissue engineering and is a potential therapeutic factor for various diseases. (2) At present, there are relatively few studies on Sema3A on oral tissue-derived mesenchymal stem cells, but it is basically confirmed that Sema3A can play an active role in the regulation of oral tissue-derived mesenchymal stem cells. (3) The inflammatory environment has a significant inhibitory effect on the proliferation and differentiation of stem cells, but studies have found that Sema3A can effectively regulate the proliferation and differentiation of a variety of oral mesenchymal stem cells in an inflammatory environment, thus playing an important role in inflammatory diseases. (4) Because Sema3A itself has the biological function of bone protection and Sema3A can effectively enhance the stem cell characteristics of oral tissue-derived mesenchymal stem cells and induce their proliferation and differentiation, it has unique advantages on regulating the differentiation of oral tissue-derived mesenchymal stem cells into bone to treat bone defect. (5) Studying that Sema3A regulates the proliferation and differentiation of oral tissue-derived mesenchymal stem cells can become a new idea for the treatment of oral diseases, and make breakthroughs in the field of soft and hard tissue repair and regeneration in the oral cavity.
Key words: Sema3A, bone remodeling, axon, tumor, oral mesenchymal stem cell, immune, proliferation, differentiation