Grophene-family nanomaterials in the treatment of periodontal disease: beneficial for osteogenic differentiation and reconstruction of periodontal support tissues
Ren Wenyan, Liu Xue, Wang Yiyu
School of Stomatology, Jining Medical University, Jining 272067, Shandong Province, China
Abstract: BACKGROUND: Grophene-family nanomaterials have received extensive attention from scholars due to their superior properties, and their properties and applications have become research hotspots. The current research mainly involves antibacterial properties, tissue engineering scaffolds, induction of odontogenic stem cell regeneration and osteogenic differentiation, which coincides with the treatment goals of periodontal disease.
OBJECTIVE: To review the research progress of grophene-family nanomaterials in the field of periodontal disease treatment, and to confirm that grophene-family nanomaterials have good application prospects in the prevention and treatment of periodontal disease.
METHODS: The relevant articles published from January 2000 to April 2022 in CNKI, Wanfang Database, ScienceDirect, PubMed, and Medline databases were searched by computer. The search terms were “grapheme, periodontal disease, biocompatibility, antibacterial mechanism, odontogenic stem cells, guided tissue regeneration”. By reading the title and abstract of the preliminary screening, the literature that was not related to the theme of the article was excluded. According to the inclusion and exclusion criteria, 67 articles were finally included for the result analysis.
RESULTS AND CONCLUSION: (1) Grophene-family nanomaterials have a good inhibitory effect on common pathogenic bacteria of periodontal disease through their own antibacterial and drug-loaded antibacterial effects. (2) Grophene-family nanomaterials can be used as tissue engineering scaffolds to carry cells and increase adhesion. It can promote cell migration and proliferation, and the growth and osteogenic differentiation of dental stem cells, which is conducive to the reconstruction of periodontal support tissues.
Key words: graphene, periodontal disease, biocompatibility, antibacterial mechanism, odontogenic stem cell, review