2023, Vol. 27 ›› Issue (18): 2935-2942

Immune complex expression and platelet-rich plasma repairing mechanism for lumbar discogenic neuralgia

Li Tusheng1, 2, Ding Yu1, 2, 3, Jiang Qiang3, Zhang Hanshuo3   

Abstract: BACKGROUND: Immune mechanism plays an important role in the occurrence and development of lumbar discogenic neuralgia. Platelet-rich plasma is one of the effective means for the treatment of lumbar degenerative diseases such as lumbar discogenic neuralgia. Exploring the expression of immune complex of lumbar discogenic neuralgia and the therapeutic mechanism of platelet-rich plasma can provide new ideas for the prevention and timely treatment of neuralgia secondary to disc degeneration.  
OBJECTIVE: To review the immune mechanism of lumbar discogenic neuralgia and the therapeutic mechanism of platelet-rich plasma, and make a prospect.
METHODS: PubMed database, CNKI database and VIP database were searched. The English and Chinese search terms were “disc degeneration, lumbar discogenic neuralgia, lumbar discogenic sciatica, sciatica, PRP, platelet rich plasma, immunological response”. After preliminary screening of all articles according to inclusion and exclusion criteria, 86 articles were finally included for review.  
RESULTS AND CONCLUSION: The role of immune mechanism in lumbar intervertebral disc degeneration has been extensively studied, and it plays a key role in the generation and development of lumbar discogenic neuralgia. Various immune inflammatory factors are the key mediators leading to nerve root pain. The treatment of lumbar discogenic neuralgia by platelet-rich plasma is mainly based on its rich growth factors, including anti-inflammatory and neuroprotection, immunomodulation, Schwann cell activation and axon regeneration, intervertebral disc degeneration repairing and angiogenesis.
Key words: platelet-rich plasma, discogenic neuralgia, discogenic sciatica, immunological response, disc degeneration, PRP, sciatica