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2023, Vol. 27 ›› Issue (2): 184-191Mechanism of Bushen Huoxue Capsule in repair of bone defects due to steroid-induced osteonecrosis of the femoral head in ratsLuo Di1, 2, Liang Xuezhen1, 2, Yan Bozhao2, Li Jiacheng1, Xu Bo1, 2, Li Gang1, 2
Abstract: BACKGROUND: Glucocorticoids can inhibit the expression of key genes in the Hedgehog signaling pathway, thereby disrupting the differentiation of bone marrow mesenchymal stem cells into osteogenesis, adipogenesis, and angiogenesis, thereby destroying the blood supply and bone tissue structure in the bone. We found that Bushen Huoxue Capsule has a certain therapeutic effect on these changes. |