2023, Vol. 27 ›› Issue (2): 307-313
Mechanism and implication of angiogenesis in osteoarthritis
Liu Yinghong1, Yi Yating2
1Jinjiang Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu 610011, Sichuan Province, China; 2Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, National Key Laboratory of Oral Disease Research, National Clinical Research Center for Oral Diseases, Chengdu 610041, Sichuan Province, China
Abstract: BACKGROUND: Osteoarthritis is one of the most common degenerative diseases worldwide. Angiogenesis plays an important role in the occurrence and development of osteoarthritis, which is involved in the process of synovitis, cartilage destruction and degeneration, and osteophyte formation. However, the specific mechanism of angiogenesis-mediated osteoarthritis and the regulatory factors affecting angiogenesis have not been determined.
OBJECTIVE: To review the pathogenesis of angiogenesis-mediated osteoarthritis, thereby providing reference for future basic research and clinical practice.
METHODS: “Osteoarthritis, angiogenesis, angiogenesis inhibitors” were used as the key words in Chinese and English, respectively, for literature retrieval in PubMed and CNKI databases. Retrieval time was from 1980 to 2021. Documents regarding the role and influential factors of angiogenesis in osteoarthritis as well as angiogenesis inhibitors in the treatment of osteoarthritis were collected, including original articles, reviews, dissertations, academic papers, etc. According to the inclusion and exclusion criteria, a total of 74 articles were selected after primary screening and re-screening through reading title, abstract and full-text.
RESULTS AND CONCLUSION: Angiogenesis promotes synovitis, cartilage destruction and degeneration, osteophyte formation, and joint pain, which is one of the important factors in the formation and exacerbation of osteoarthritis. The influential factors are angiogenic factors, inflammatory cytokines, interaction between nerves and vessels, exosomes, and non-coding RNAs. Therefore, inhibiting angiogenesis is a potent target for osteoarthritis therapy. Up to date, angiogenesis inhibitors are only confined to vitro experiments and animal models and their clinical application in osteoarthritis should be further discussed.
Key words: osteoarthritis, angiogenesis, factor, angiogenesis inhibitor, non-coding RNA, review