2023, Vol. 27 ›› Issue (3): 441-446

Research progress in platelet-rich fibrin in stomatology

Chen Jingqiao, Li Ying, Meng   Maohua, Xu Xingxing, Wang Qinying, Wang Huan, Lu Jing, Shu Jiayu, Dong Qiang   

Abstract: BACKGROUND: Platelet-rich fibrin is a second-generation platelet concentrate that has been applied in many fields of dentistry. However, there is no conclusive evidence to explain its effect on promoting the healing and preservation of soft and hard tissues.
OBJECTIVE: To review the current research overview of platelet-rich fibrin in stomatology.
METHODS: Relevant literature published from 2001 to 2021 was searched in CNKI and PubMed databases with the search terms of “platelet-rich fibrin, stomatology” in Chinese and English, respectively. The search time limit was extended for some classical literature. The abstracts and contents of the retrieved literature were analyzed, and 53 eligible documents were obtained as per inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Although it has been documented that platelet-rich fibrin has a good effect in the repair and reconstruction of soft and hard tissues in oral diseases, the current evidence does not clearly explain the mechanism. In addition, the preparation methods of platelet-rich fibrin are not yet the same and there are a wide variety of platelet-rich fibrin derivatives and different centrifugation methods. Therefore, a large number of experiments are still needed in the future.
Key words: platelet-rich fibrin, platelet-rich concentrate, dental implantation, stomatology, biological characteristics, review