2023, Vol. 27 ›› Issue (3): 447-452

Application of carboxymethyl chitosan in tissue engineering of stomatology

Zong Mingrui, Liu Haiyan, Li Bing, Wu Xiuping   

Abstract: BACKGROUND: As a derivative of natural biological material chitosan, carboxymethyl chitosan has a wide application prospect in tissue engineering due to its unique water-solubility, film-forming and sustained-release properties.  
OBJECTIVE: To review the advantages of carboxymethyl chitosan compared with chitosan and its application in oral tissue regeneration.  
METHODS: PubMed and CNKI were searched using the key words of “carboxymethyl chitosan AND Tissue engineering, carboxymethyl chitosan AND (dentistry OR stomatology)” for articles published from January 2006 to October 2021. Preliminary screening was conducted through reading and analysis to exclude duplicate articles and low-correlation articles. Eventually, 51 articles were included for result analysis.
RESULTS AND CONCLUSION: Carboxymethyl chitosan, as a non-toxic material with valuable biocompatibility and biodegradation, has made ideal progresses in bone tissue regeneration, tooth tissue regeneration and periodontal tissue regeneration. Carboxymethyl chitosan has better water solubility, membrane formation and ion binding properties than chitosan, which greatly expands its application in oral tissue engineering. Carboxymethyl chitosan has achieved the expected experimental results whether it is used alone to exert antibacterial effect and promote cell proliferation and differentiation, or used as a scaffold material, hydrogel, modified material and biological active ingredients and growth factors.
Key words: carboxymethyl chitosan, chitosan derivatives, tissue engineering, oral tissue construction, periodontal regeneration, remineralization, bone regeneration