|
2023, Vol. 27 ›› Issue (31): 5071-5077Properties, functions and applications of three-dimensional models of bone for drug screeningHuang Miao1, Wu Xiesheng2, Huang Wenshi2, Huang Haina1, Chen Longyun1, Peng Weijie1
Abstract: BACKGROUND: The development of drugs for skeletal-related diseases in clinical settings is a lengthy process, and the effectiveness of traditional two-dimensional models for drug screening no longer meets the needs. Various modified 3D models have their advantages and disadvantages and related applications, but so far there is no ideal experimental model that can be utilized for drug screening of all bone related diseases. Key words: stem cell, three-dimensional culture, skeletal disease, three-dimensional model, drug screening, cell sphere, hydrogel, bioprinting, tissue engineering, review |