2023, Vol. 27 ›› Issue (4): 619-625

Hippo signaling pathway in the regulation of spinal cord injury

Tao Xin1, 2, Xu Yi1, Song Zhiwen1, Liu Jinbo1

1The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China; 2Department of Orthopedics, People’s Hospital of Liyang, Changzhou 213300, Jiangsu Province, China

Received:2022-03-16 Accepted:2022-05-09 Online:2023-02-08 Published:2022-06-23
Contact: Liu Jinbo, MD, Chief physician, Professor, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Song Zhiwen, Master, Physician, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
About author:Tao Xin, Doctoral candidate, Associate chief physician, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China; Department of Orthopedics, People’s Hospital of Liyang, Changzhou 213300, Jiangsu Province, China Xu Yi, Master candidate, The Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Tao Xin and Xu Yi contributed equally to this article.
Supported by:
the National Natural Science Foundation of China (General Program), No. 81972048 (to LJB); National Natural Science Foundation of China (Youth Project), No. 81901247 (to SZW)

Abstract: BACKGROUND: Recent studies have shown that Hippo signaling pathway is closely related to pathological changes after spinal cord injury. Through targeted regulation of this signaling pathway, it can provide new ideas for the treatment of spinal cord injury in clinical practice.
OBJECTIVE: To review the research progress of regulatory mechanism of Hippo signaling pathway in spinal cord injury.
METHODS: PubMed and Web of Science databases were searched by the first author. Search terms were “spinal cord injury, nervous system, Hippo signaling pathway, MST1/2, LATS1/2, MOB1A/B, NDR1/2, YAP, TAZ, neurite, axonal regeneration, myelination, neuronal death, inflammation, glial scar, gliosis”. The search time limit was from September 2007 to February 2022. The articles unrelated to the purpose of this study and repeatability were excluded. Finally, 62 articles that met the criteria were included for review.
RESULTS AND CONCLUSION: Hippo signaling pathway molecules are widely expressed in neuronal cells and YAP regulates central neural development and maintains a dynamic balance of neuronal proliferation and differentiation. In the pathological mechanism of secondary spinal cord injury, the Hippo pathway plays a regulatory role: (1) NDR, MOB1 and YAP molecules can promote the growth of neuropil. (2) YAP/TAZ has an important role in the synthesis of myelin and the dynamic regulation of myelin growth. (3) Inhibition of Hippo pathway expression can reduce neuronal apoptosis and neurological deficits. (4) Both glial cells and fibroblasts can be modulated by YAP to influence glial scar formation. Numerous studies have shown that regulation of Hippo pathway provides new ideas and therapeutic strategies for molecular targeting therapy and development of biomaterials for spinal cord injury.
Key words: Hippo signaling pathway, spinal cord injury, nervous system, YAP/TAZ, review

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