2023, Vol. 27 ›› Issue (5): 765-771

MicroRNA, long non-coding RNA and circular RNA mediate the mechanism of decreasing uric acid, anti-inflammation and regulating bone metabolism in gout

Shao Zichen1, Li Huanan2, Gu Bing3, Zhang Xiaoyun1, 4, Sun Weikang1, Liu Yongqian1, Gan Bin1   

Abstract: BACKGROUND: In the past decade, significant progress has been made in the understanding of the pathogenesis, effects, diagnostic methods and treatments of gout, but the pathogenesis of gout has not yet been clarified. A large number of experimental studies have shown that microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are closely related to the occurrence and development of gout.
OBJECTIVE: To review the mechanism of miRNA, lncRNA and circRNA in different stages of gout development.
METHODS: The Chinese search terms were “Gout; Hyperuricemia; Gouty Arthritis; lncRNA; miRNA; circRNA; RNA” and the English search terms were “Gout; Arthritis, Gouty; Gouty Arthritis; Arthritides, Gouty; Gouty Arthritides; Hyperuricemia; RNA; Gene Products, RNA; RNA Gene Products; RNA, Non Polyadenylated; Non Polyadenylated RNA; Ribonucleic Acid.” PubMed, Embase, CNKI, WanFang, VIP and other databases were retrieved respectively. The search time range was 2013 to 2022. By reading the titles and abstracts of the literature, the low-quality, repetitive and irrelevant articles were excluded and 53 highly relevant articles were included in the review.
RESULTS AND CONCLUSION: MiRNA, lncRNA, and circRNA are expected to become new targets and strategies for reducing uric acid levels, repairing immune balance, reducing inflammation and regulating osteoclast activation, which will become biomarkers for gout treatment. In the follow up study, we should strengthen the research on the mechanism of epigenetics in human body and also pay attention to the co-regulation of many kinds of non-coding RNAs.
Key words: long non-coding RNA, gout, hyperuricemia, circRNA, inflammatory response, bone metabolism, signal pathway, microRNA