2023, Vol. 27 ›› Issue (5): 787-792

Application potential of naringin in bone tissue regeneration

Zhang Min, Zhang Xiaoming, Liu Tongbin   

Abstract: BACKGROUND: Bone tissue regeneration is currently an important research direction in the treatment of large-area bone defects. Naringin, as a natural flavonoid, has the potential to induce osteogenesis, which has attracted extensive attention in the field of bone tissue regeneration.
OBJECTIVE: To review the main related effects and safety of naringin in promoting bone regeneration and its application in bone tissue engineering, thereby providing a theoretical basis for the clinical treatment of large-area bone defects.
METHODS: The first author searched for articles regarding naringin-induced osteogenesis included in PubMed, WanFang, and CNKI databases from 2002 to 2021. The keywords were “naringin; bone defects; osteoinductive; osteoporosis; bone regeneration; osteoclasts; blood vessel; bone tissue engineering” in English and Chinese, respectively. Fifty-five eligible articles were finally reviewed.
RESULTS AND CONCLUSION: Naringin has a good potential of inducing bone tissue production in anti-osteoporosis, promoting bone formation, inhibiting osteoclast formation and promoting angiogenesis by exerting estrogen-like effects or participating in the regulation of different signaling pathways such as bone morphogenetic protein, Wnt/β-catenin, PI3K/Akt and VEGF/VEGFR-2. In addition, naringin has the characteristics of safety, stability, easy extraction, and low cost. Therefore, naringin is a very promising natural bone induction small-molecule drug. In recent years, naringin combined with bone tissue engineering technology has improved the initial sudden release and bioavailability of drugs. However, in the future, we still need more experimental studies on the mechanism of induction osteogenesis in a more comprehensive and systematic way, and make full use of good bone tissue engineering technology to further verify the most suitable controlled-release carrier and local application effect of naringin. Thereby, naringin will be mature, stable and effective in the clinical treatment of bone defects as soon as possible.
Key words: naringin, bone defect, osteoinductive, osteoporosis, bone regeneration, osteoclast, blood vessel, bone tissue engineering