2023, Vol. 27 ›› Issue (5): 793-798

Effect of hypoxic training on the oxygen sensing pathway

Liu Yuan   

Abstract: BACKGROUND: Hypoxic training is a training method that utilizes the dual stimulation of hypoxia and exercise to mobilize the potential of athletes and improve athletic performance. Oxygen sensing is the ability of cells to sense oxygen and adapt to oxygen, which is regulated by many key factors in cells, such as hypoxia-inducible factors, which in turn form an oxygen sensing pathway. This pathway plays an important role in hypoxic training.
OBJECTIVE: From the perspective of how the body cells perceive oxygen and adapt to hypoxia during hypoxic training, to explore the physiological mechanism by which hypoxic training promotes exercise health and improves exercise performance.
METHODS: A literature search of CNKI and PubMed was conducted using the keywords of “oxygen-sensing, hypoxic training, hypoxia inducible factor” in Chinese and English, respectively. After title, abstract and main text reading, 50 articles were finally included for review.
RESULTS AND CONCLUSION: Hypoxia-inducible factors are important regulators in the oxygen sensing pathway. Hypoxic training can significantly upregulate the expression of hypoxia-inducible factor-1, enhance glucose metabolism, oxygen transport and angiogenesis in tissues, providing theoretical support for hypoxic training to prevent and alleviate hypoxia-induced cardiovascular diseases through the oxygen sensing pathway. The hypoxia-inducible factor signaling pathway may play its value as a new therapeutic target to improve human tissue function in the future and the elucidation of the mechanism by which hypoxia-inducible factors act on cellular sensing and response to oxygen levels opens up new fields for biology and medicine.
Key words: oxygen sensing, hypoxic training, hypoxia-inducible factor, cell, review