2023, Vol. 27 ›› Issue (7): 1103-1109

Osteoinductive properties of calcium phosphate ceramic bone repair materials

Lu Di1, Zhang Cheng1, Duan Rongquan1, Liu Zongxiang1, 2   

Abstract: BACKGROUND: Autologous bone transplantation, allograft and xenograft are common methods for bone defect repair in clinical practice, but their application is limited by insufficient donor number, increased surgical trauma and immune rejection. The physical and chemical structures of synthetic calcium phosphate ceramic repair material are similar to those of natural bone tissue, and its porous micro-nano morphology and surface bioactive ions make it have excellent osteoinduction and bone inductive potentiality, which has a wide application prospect in the repair and treatment of bone defects.
OBJECTIVE: To provide new ideas for the repair of bone defects in clinical diagnosis and treatment by reviewing the common forms, physicochemical properties and osteoinductive properties of calcium phosphate ceramic materials.
METHODS: The literature search was performed in CNKI, Wanfang, Web of Science, and PubMed databases. The keywords were “calcium phosphate ceramic, bone-repair, bone defects, osteoinduction, bone inductive potentiality” in Chinese and English. According to the inclusion and exclusion criteria, 59 articles were finally reviewed.
RESULTS AND CONCLUSION: Hydroxyapatite, tricalcium phosphate and biphasic calcium phosphate are calcium phosphate ceramic materials most commonly used in bone repair. Through continuous improvement of their preparation process and surface modification, they have good biocompatibility, biodegradability and bone induction. By regulating its macrostructure, micronano surface morphology (aperture, roughness, etc.), calcium and phosphorus release and protein adsorption, the osteogenic induction process is directly or indirectly affected. The interaction of calcium phosphate ceramics with inflammatory cells (monocytes, macrophages, osteoclasts) has led to more surface feature formation with osteoinductive properties and higher concentration of Ca2+, PO43- and associated factors, which has achieved good bone induction results in both in vitro and vivo studies.
Key words: bone defect, calcium phosphate, bone repair, osteoinduction, bone inductive potentiality, review