2023, Vol. 27 ›› Issue (8): 1219-1223

Influence of blood components on blood flow characteristics of individualized communicating aneurysm

Wu Chuang1, Muhetaer · Kelimu1, Maimaitili · Aisha2, Yang Hang1   

Abstract: BACKGROUND: Hemodynamics plays an indispensable role in the occurrence and development of aneurysms, but the mechanism of occurrence and rupture of aneurysms is still unclear.
OBJECTIVE: To analyze the influence of blood components on the rupture of aneurysm and to explore the mechanism of blood components on the rupture of aneurysms.
METHODS: CT images of a 52-year-old female patient with posterior communicating artery aneurysm were acquired and imported into MIMICS 20.0 to establish a surface model of the aneurysm. The model was processed by Geomagic Studio software to export the three-dimensional vascular wall model. The blood was assumed to be single-phase flow and two-phase flow, and computational fluid dynamics was used to numerically simulate the blood flow in the aneurysm and the tumor-bearing artery and analyze the influence of blood components on hemodynamic characteristics, including blood streamline velocity, wall deformation and displacement, wall shear stress, and relative stagnation time.
RESULTS AND CONCLUSION: At the same time, the blood flow patterns in the two models remained consistent. Compared with the single-phase flow model, the two-phase flow model had a higher proportion of low-wall shear stress area and greater deformation displacement, and larger area of near-wall stagnation for a relatively long time. Compared with the single-phase flow model, the two-phase flow model was more likely to damage vascular wall endothelial cells, resulting in structural and functional abnormalities. Moreover, the two-phase flow model was more likely to form a thrombus, causing the obstruction of tumor-bearing aneurysms induced by thrombus shedding. To conclude, the two-phase flow model has greater displacement, that is, greater stress. Under this condition, the aneurysm is more likely to rupture.
Key words: fluid-solid coupling, two-phase flow, wall shear stress, relative stagnation time, blood composition, inlet condition, three-dimensional model, wall displacement, aneurysm