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2024, Vol. 28 ›› Issue (26): 4113-4120Effects of aerobic exercise on the expression of Notch1 and Caspase-3 in the hippocampus of Alzheimer’s disease miceYang Liyuan1, Zhang Yeting2, Li Chuikun1, Wei Cuilan3
Abstract: BACKGROUND: β-amyloid protein and Tau protein have adverse effects on the cognitive function of Alzheimer’s disease patients, and Notch1 and Caspase-3 can regulate the expression of β-amyloid protein and Tau protein. It is not clear whether Notch1 and Caspase-3 mediate the process of aerobic exercise to improve the cognitive ability of Alzheimer’s disease patients. At present, there is a lack of studies on the effect of long-term aerobic exercise on the expression of Notch1 and Caspase-3 in the hippocampus of Alzheimer’s disease mice. Key words: Alzheimer’s disease, aerobic exercise, learning and memory ability, Notch1, Caspase-3 |