2024, Vol. 28 ›› Issue (26): 4145-4150
Visual analysis of the effect of apoptosis on ischemic stroke
Duan Yanzhe1, Hua Jianlin1, 2, Ding Zhibin1, 3, Jiang Nan4, Song Lijuan1, 4, Yan Yuqing1, 5, Ma Cungen1, 5
1Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center, State Administration of Traditional Chinese Medicine, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi Province, China; 2Department of Neurosurgery, Sinopharm Coal Group General Hospital, Datong 037003, Shanxi Province, China; 3Shanxi Bethune Hospital (Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences), The Third Hospital of Shanxi Medical University, Taiyuan 030032, Shanxi Province, China; 4Key Laboratory of Cell Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 5Department of Neurology, Institute of Brain Science, The First Affiliated Hospital of Shanxi Datong University, Datong 037009, Shanxi Province, China
Abstract: BACKGROUND: Ischemic stroke is a highly prevalent disease associated with apoptosis. Neuronal death occurs after cerebral ischemia, including necrosis and apoptosis. The ischemic core region is dominated by necrosis, while delayed neuronal death in the penumbra is dominated by apoptosis. The penumbra has become a target for the treatment of ischemic stroke. This bibliometric analysis was used to identify the characteristics, hotspots, and frontiers of global scientific output related to apoptosis in ischemic stroke over the past 5 years.
OBJECTIVE: To analyze the role of apoptosis and its mechanisms in the pathological process of ischemic stroke through a bibliometric approach.
METHODS: A total of 927 relevant literature records from 2018 to 2022 were retrieved from Science Citation Index Expanded (SCI-Expanded) and Social Science Citation Index Expanded (SSCI-Expanded) of the Web of Science Core Collection. Research trends and hotspots of apoptosis in ischemic stroke were visualized using Citespace, VOSviewer and Bibliometrix.
RESULTS AND CONCLUSION: From 2018 to 2020, the number of papers on the role of apoptosis in ischemic stroke showed an upward trend, but in 2020, the number of papers began to reduce. China had the largest number of publications, and the United States ranked the second. Capital Medical University and BRAIN RESEARCH BULLETIN were the institutions and journals with the most articles, respectively. In recent years, the two keywords “expression” and “oxidative stress” have appeared more frequently. The bibliometric study showed that in the past 5 years, most of the studies focused on basic research, in which research on the role of apoptosis in ischemic stroke has gradually decreased in the last 3 years, showing a downward trend. On the contrary, nerve regeneration has gradually become a research hotspot, especially the regulation of neurotrophic factors under the influence of different mechanisms, and the research on angiogenesis and glial cell repair is on the rise. At the same time, apoptosis in nerve regeneration is a potential point of discovery.
Key words: bibliometrics, cell apoptosis, ischemic stroke, VOSviewer, Citespace