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2024, Vol. 28 ›› Issue (28): 4469-4476Metformin pretreatment induces cardiac autophagy to reduce myocardial injury in septic miceTian Yong1, 2, Zhou Ying1, Gu Yongxiang1, Yang Guohui3
Abstract: BACKGROUND: Sepsis complicated by myocardial injury is characterized by a high mortality. Metformin can prevent sepsis-induced myocardial dysfunction by exerting anti-inflammatory effects, improving oxidative stress, and reducing apoptosis. However, it is unclear whether metformin-induced autophagy plays an important role in the protective effect against sepsis-induced myocardial injury. Key words: metformin, autophagy, sepsis, inflammatory response, myocardial injury |