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2024, Vol. 28 ›› Issue (28): 4491-4497Significance of PI3K/Akt/HIF-1α signaling pathway expression in nucleus pulposus cells at different oxygen concentrations in delaying intervertebral disc degenerationZhou Minghan, Zhang Hui, Zheng Xianbo, Xu Wuji
Abstract: BACKGROUND: Intervertebral disc degeneration is a condition caused by the combined effects of various factors, such as cellular apoptosis, oxidative stress, and inflammatory responses. Currently, it is believed that the core of this condition lies in the degeneration and apoptosis of nucleus pulposus cells (NPCs). However, the specific pathological mechanisms remain unclear. Key words: oxygen concentration, nucleus pulposus cell, cell apoptosis, oxidative stress, biological characteristics, signaling pathway |