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2024, Vol. 28 ›› Issue (36): 5759-5765

Biomechanical characteristics of thoracic T10 bone tumor metastasis at different locations: three-dimensional finite element analysis

Xia Guoren1, Yu Hao1, Jiang Shifeng1, Peng Xin1, Fu Xiao1, Chen Qi1, Yang Lizhuang1, 2, Wang Tengfei1, 2, Li Hai1, 2   

  1. 1Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China; 2Hefei Institute of Materials, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China

  • Received:2023-08-29 Accepted:2023-11-16 Online:2024-12-28 Published:2024-02-27

  • Contact: Li Hai, MD, Researcher, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China; Hefei Institute of Materials, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China

  • About author:Xia Guoren, Master, Attending physician, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230000, Anhui Province, China

Abstract: BACKGROUND: With the innovation of examination technique, the number of patients with spinal metastases in different stages is increasing year by year. Percutaneous vertebroplasty is an important treatment for spinal metastases; however, there is no report on the biomechanical effect in different stages and different activities after operation.
OBJECTIVE: To simulate thoracic T10 bone stress and displacement of the different locations of the tumor metastasis based on the three-dimensional finite element model.
METHODS: According to thoracic three-dimensional CT images of a 30-year-old healthy male, Mimics software was used to construct a three-dimensional geometric model of thoracic vertebrae (T9-T11), including ribs, ligaments and intervertebral discs. Three-dimensional models of T9-T11 vertebral bodies and different parts of the posterior thoracic vertebrae invaded by thoracic metastatic tumors were simulated, including the control group with intact vertebral structure, unilateral metastasis involving the vertebral body area (experimental group 1), unilateral metastasis involving the vertebral body and pedicle area (experimental group 2), unilateral metastasis involving the vertebral body, pedicle and transverse process area (experimental group 3), and bilateral metastasis involving the vertebral body, pedicle and transverse process area (experimental group 4). Abaqus software was used to create a three-dimensional finite element model. The von Mises stress distribution and the displacement of the model were analyzed under the loading condition, buckling condition, extension condition, and rotation condition.
RESULTS AND CONCLUSION: (1) In the study of the maximum total displacement of loading points in different experimental groups under loading, flexion, extension, and rotation conditions, with the increase of metastatic tumor invasion site and invasion surface, the total displacement of loading points increased, and the overall stiffness decreased, especially the total displacement of loading points in experimental group 4 was the largest. (2) Under flexion condition, the maximum Von Mises stress value increased significantly after vertebral body and pedicle destruction, while the maximum Von Mises stress value was almost unchanged when the thoracocostal joint destruction was added. (3) On the basis of finite element analysis and simulation of bone tumor model, the elements in the bone cement region were set as a single set, and the bone cement region was set as the corresponding material properties to simulate bone cement filling. The results showed that the maximum total displacement under loading, flexion, extension, and rotation conditions was less than that of each experimental group. (4) The maximum stress values of the simulated percutaneous vertebroplasty patients in the loading, flexion, extension and rotation conditions were significantly lower than those of the femoral model. (5) It is concluded that the three-dimensional finite element model based on thoracic T9-T11 conducive to the biomechanics characteristics of thoracic vertebrae tumor metastasis, and on the basis of the thoracic vertebrae tumor metastasis model can accurately simulate load point after percutaneous vertebral body under different conditions of total displacement and the maximum Von Mises stress situation.

Key words: spinal metastases, percutaneous vertebroplasty, bone cement, finite element model, biomechanics analysis


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