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2024, Vol. 28 ›› Issue (36): 5828-5832

Unicompartmental knee arthroplasty in treatment of medial compartment osteoarthritis of knee joint: joint function and changes in inflammatory cytokines

Li Yuxuan, Yuan Lingli, Xu Zhiyuan, Yan Tao, Zhang Zhongchuan, Xu Wendi, Zhu Xunbing   

  1. Department of Orthopedics, Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China

  • Received:2023-11-22 Accepted:2023-12-22 Online:2024-12-28 Published:2024-02-28

  • Contact: Zhu Xunbing, MD, Professor, Chief physician, Master’s supervisor, Department of Orthopedics, Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China

  • About author:Li Yuxuan, Master candidate, Department of Orthopedics, Second Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China

  • Supported by:

    Graduate Research Innovation Program of Bengbu Medical College, No. Byycx22135 (to LYX); Natural Science Research Project of Anhui Educational Committee, No. KJ2021A0756 (to YLL)


Abstract: BACKGROUND: Unicompartmental knee arthroplasty has been paid more and more attention because of its advantages of fewer traumas, less blood loss, less complications, faster recovery, excellent knee function and high prosthetic survival rate. Most of the relevant reports focused on its clinical effect, but the changes in the levels of relevant inflammatory cytokines in patients after unicompartmental knee arthroplasty were rarely reported.
OBJECTIVE: To investigate the effect of unicompartmental knee arthroplasty in patients with medial compartment osteoarthritis of the knee and the changes of interleukin-1, interleukin-6, and tumor necrosis factor-α levels.
METHODS: A total of 30 patients with medial compartment osteoarthritis of the knee who received unicompartmental knee arthroplasty from September 2021 to March 2023 and met the inclusion criteria were selected as the study subjects. Medial angle of proximal tibia, femoral and tibial angle, pain visual analog scale score, hospital for special surgery score, knee joint range of motion, synovial fluid interleukin-1, interleukin-6, and tumor necrosis factor-α levels before and after surgery were compared and statistically analyzed.
RESULTS AND CONCLUSION: (1) All 30 patients had grade I wound healing. All patients were followed up for more than 6 months after surgery. There were no complications such as prosthesis loosening and dislocation of prosthesis liner in all patients. (2) The medial proximal tibia angle and the femoral and tibial angles measured after operation were significantly improved (P < 0.05). (3) The visual analog scale score, hospital for special surgery score and range of motion measured at 1, 3, and 6 months after operation were better than those before operation (P < 0.05), and showed a gradual improvement (P < 0.05). (4) The levels of interleukin-1, interleukin-6, and tumor necrosis factor-α in synovial fluid at 3 and 6 months after operation were decreased gradually compared with those before operation (P < 0.05) and showed a gradual downward trend at each time point after operation. (5) It is indicated that unicompartmental knee arthroplasty can effectively treat medial compartment osteoarthritis of the knee, significantly relieve pain, restore knee joint function, improve knee varus deformity and lower limb strength line, and reduce the levels of inflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-α in joints to a certain extent.

Key words: osteoarthritis, unicompartmental knee arthroplasty, hospital for special surgery score, interleukin-1, interleukin-6, tumor necrosis factor-α


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