2025, Vol. 29 ›› Issue (34): 7405-7414

Effects of scaffold materials combined with biological factors on biological characteristics of dental follicle cell proliferation and osteogenic differentiation

Li Zhongzheng1, 2, Chen Zhenghao1, 2, Tang Ziyou1, 2, Lou Kaiyang1, 2, Zhang Rui1, 2, Liu Qi1, 2, Zhao Na1, 2, Yang Kun1, 2   

Abstract: BACKGROUND: Dental follicle cells are widely used in periodontal tissue regeneration engineering because of their excellent characteristics. With the development of biological scaffold materials, their relationship with periodontal tissue regeneration technology is increasingly close.
OBJECTIVE: To review the performance of ivory follicle cells under the influence of internal and external biological factors by different experiments, and analyze their effects on the biological characteristics of dental follicle cells with scaffold materials.
METHODS: Using “dental follicle cell, scaffolds, material, periodontal tissue regeneration, tissue engineering, review” as English and Chinese key words, the articles published in PubMed, Sciencedirect, and CNKI from 2013 to 2023 were searched, and finally 95 articles were included for analysis and discussion.
RESULTS AND CONCLUSION: (1) Dental follicle cells originate from dental follicle tissue, which has certain stem cell differentiation potential. Because of its excellent performance, it is actively used in periodontal tissue regeneration engineering research. (2) The proliferation and osteogenic differentiation of dental follicle cells are affected by many biological factors, and both endogenous and exogenous factors can promote the proliferation and osteogenic differentiation of dental follicle cells to a certain extent. (3) 3D printing technology and nanotechnology enable researchers to manufacture more suitable scaffold materials. (4) Polymer materials show us their flexibility and plasticity in periodontal tissue regeneration. We can manufacture targeted scaffold materials according to different defect sites to achieve efficient tissue regeneration. The good biocompatibility of inorganic materials makes them widely used in periodontal tissue regeneration engineering. By adjusting the content of nanoscale inorganic materials or improving the performance of scaffolds, scaffolds with better biocompatibility can be prepared. (5) There are many new synthetic (composite) materials, which show us excellent characteristics. However, because the mechanism of biological factors in scaffold materials on dental follicle cells is complicated, and the research on dental follicle cells is mostly concentrated on in vitro culture, so how to make scaffold materials more suitable for the growth and development of dental follicle cells and apply them safely and effectively in clinical treatment is the future research direction.

Key words: dental follicle cell, scaffold material, biological factor, signaling pathway, microenvironment, periodontal tissue regeneration, tissue engineering, review